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Methyl Folate 5-MTHF
600µg of Quatrefolic 5-MTHF per capsule (300% NRV) · one a day · 90 vegan capsules · a 3-month supply
- 600µg of 5-MTHF per capsule, the form folate already takes in your body
- Quatrefolic, a patented and well characterised 5-MTHF rather than a generic one
- Folate contributes to the reduction of tiredness and fatigue and to normal blood formation
- One capsule a day, 90 per bottle, so three months for 16p a day
£0.16 a day · at 1 capsule a day · 3 months per bottle
Three months from one bottle, at a capsule a day.
Multi-buy discount applied automatically at checkout
Why choose our Methyl Folate
The active form of folate at a proper dose, one capsule a day, and a bottle that lasts a full three months.
Folic acid has to be converted before your body can use it. 5-MTHF arrives as the finished article, which is the whole reason people look for this form.
Folate contributes to the reduction of tiredness and fatigue, and to normal psychological function.
Folate contributes to normal blood formation, to normal homocysteine metabolism, and to normal amino acid synthesis.
90 vegan capsules, one capsule a serving, no splitting and no counting. Around 16p a day.
What the methylated form actually means
Folate from food and from standard folic acid supplements has to be converted by your body before it can be put to work. The last step of that conversion produces 5-MTHF. An enzyme called MTHFR does the work, and how efficiently people manage it varies.
This capsule starts at the end of that chain. Quatrefolic is 5-MTHF already, so nothing has to act on it first. That is the entire case for the methylated form, and it is enough of a reason on its own. What we will not do is tell you that you need a gene test, or that folic acid does not work, because neither is true.
With water, at whatever time you will remember. 600µg, which is 300% of the reference intake.
Folate is water soluble and not stored in quantity, so a daily habit matters more than the timing.
90 capsules at one a day. Long enough that you are not reordering constantly.
How our methyl folate compares
Most folate supplements are folic acid at 200 to 400µg, and plenty ask you to take two capsules to get there.
| Our Methyl Folate | Typical folate supplement | |
|---|---|---|
| Folate form | 5-MTHF (Quatrefolic) | Usually folic acid |
| Amount per capsule | 600µg (300% NRV) | Often 200 to 400µg |
| Capsules per serving | One | Often two |
| Capsules per bottle | 90, a 3-month supply | 60 |
| Cost per day | £0.16 | Typically higher |
| Vegan capsule shell | Varies | |
| Made in the UK | Varies |
How to run it
One capsule daily with water. Most people attach it to breakfast so it is not forgotten.
Folate is not stored in quantity, so the daily habit is the point. One bottle covers the full three months.
Folate and B12 work closely together. If you take one at a high level it is worth knowing where you stand on the other.
Product details
Description
Methyl Folate Capsules - 5-MTHF Quatrefolic 600ug for Superior Folate Delivery
Standard folic acid needs to be converted by the body before it can be used, and not everyone converts it efficiently. Supplements Wise Methyl Folate uses Quatrefolic 5-MTHF, a bioavailable form of folate that the body can put to work directly. Each vegan capsule delivers 600ug (300% NRV) in a simple one-a-day format.
Why Quatrefolic 5-MTHF ![]()
Makes the Difference
Quatrefolic is a patented, glucosamine salt form of 5-methyltetrahydrofolic acid. Unlike standard folic acid, 5-MTHF is already in its active form, meaning it does not rely on the MTHFR enzyme pathway for conversion. This makes it a practical choice for adults who want to ensure their folate intake is being used efficiently by the body. Folate contributes to normal amino acid synthesis, normal blood formation, and normal psychological function.
What You Get in Every Bottle
- 600ug Methyl Folate per capsule as Quatrefolic 5-MTHF (300% NRV)
- 90 vegan capsules providing a full three-month supply
- One-a-day dosing for a simple, consistent daily routine
- HPMC capsule shell suitable for vegetarians and vegans
- UK manufactured under strict GMP standards
Clean, Transparent Ingredients
Each capsule contains glucosamine salt of (6S)-5-methyltetrahydrofolate (as Quatrefolic), with maltodextrin as a bulking agent and an HPMC capsule shell. There are no artificial colours, binders, or unnecessary fillers. Every batch is produced in the UK to strict Good Manufacturing Practice standards, giving you full confidence in what you are taking.
Who Is Methyl Folate For?
- Adults seeking a bioavailable folate supplement that does not rely on the standard folic acid conversion pathway
- Women planning pregnancy or in early pregnancy where supplemental folate contributes to maternal tissue growth during pregnancy
- Anyone looking to support normal blood formation and normal homocysteine metabolism
- Those on restricted diets who may not get enough folate from food alone
How to Take Methyl Folate
Take 1 capsule each day with water. Do not exceed the stated serving. Each bottle provides a generous 90-day supply, making it one of the longest-lasting folate supplements available. Store in a cool, dry place out of reach of children. Not suitable for children. If you are on medication, under medical supervision, pregnant, or nursing, always consult your GP before taking supplements.
Browse More B Vitamin Supplements
Explore our full range of B vitamins and folate options in the Vitamin B Supplements Collection to find the right support for your daily routine.
Ingredients & nutritionals
Folic Acid as 5-Methyltetrahydrofolic Acid 600µg (300% NRV*) Glucosamine 377µg *NRV = Nutrient Reference Value Bulking Agent: Maltodextrin, Capsule Shell: Hydroxypropyl Methylcellulose, Glucosamine Salt of (6S)-5-Methyltetrahydrofolate: (Folic Acid as 5-Methyltetrahydrofolic Acid, Glucosamine) as Quatrefolic®.Â
How to take
Take 1 capsule each day with water. Each capsule provides 600µg of folate as 5-MTHF, 300% NRV. A 90-capsule bottle is a full 3-month supply.
Do not exceed the stated serving. Not suitable for children. This is a food supplement and should be used alongside a balanced, varied diet, not as a substitute. If you are on medication, under medical supervision, pregnant, or nursing, consult your GP before use. Store in a cool, dry place out of reach of children.
Cautions
If you are on medication, under medical supervision, pregnant or nursing always consult your GP before taking health supplements. You should not take supplements as a substitute for a varied balanced diet. Side-effects from this supplement are rare but please discontinue use and contact your GP immediately in the event of an adverse reaction. Store in a cool, dry place out of reach of children.
Shipping & returns
Free UK shipping on all UK orders. Dispatched within 1 working day, Royal Mail 48. Covered by our 30-day money-back guarantee. Return within 30 days for a full refund.
Frequently asked questions
Methyl folate or folic acid, which should I buy?
They are both folate, and for most people either will do the job. The difference is what your body has to do with it.
Folic acid is converted in the body before it can be used. It is the form used in food fortification and in the great majority of the research, and it is what official guidance refers to.
5-MTHF, this one, is already the form folate takes once that conversion has happened. Nothing has to act on it first.
Choose this if you prefer the converted form, or you have been advised to take it. Choose our Folic Acid Gummies if you want the form the official guidance names, particularly around pregnancy, or if you would rather chew something than swallow a capsule.
I have heard about MTHFR. Do I need a gene test?
No, and we are not going to tell you that you do.
MTHFR is the enzyme that converts folic acid into its active form, and common variations in the gene for it mean some people convert less efficiently than others. Those variants are widespread rather than rare. What is far less settled is how much difference that makes to a healthy person's day-to-day folate status, and you will find a great deal written online that runs well ahead of the evidence.
Our position is simpler. If you would rather take the form that skips the conversion step, that is a perfectly good reason to buy this on its own. You do not need a test result to justify it, and you should be wary of anyone selling you one alongside a supplement.
Can I take this if I am pregnant or trying to conceive?
Speak to your midwife or GP first, and here is the honest answer about the two products.
UK guidance for pregnancy names folic acid at 400µg specifically. That is the form and the amount the trials behind the guidance used. Our Folic Acid Gummies deliver exactly that, and if you are supplementing because of pregnancy guidance, that is the one to buy.
Folate in general contributes to maternal tissue growth during pregnancy, and plenty of people take 5-MTHF through pregnancy on their clinician's advice. But we are not going to imply this capsule is interchangeable with the thing the guidance actually names. Ask your midwife which they want you on.
Should I be taking B12 alongside it?
It is worth thinking about, and this matters more at 600µg than at a lower dose.
Folate and B12 are closely linked. A high folate intake can correct the blood picture that a B12 deficiency would otherwise produce, which means a deficiency can go unnoticed for longer while other effects continue. It does not cause the deficiency, but it can hide it.
That is most relevant if you are vegan or vegetarian, over 60, take metformin or long-term stomach acid reducers, or have had gut surgery. If any of those apply, ask your GP about checking your B12, or take one alongside. Our Vitamin B12 is the methylcobalamin form, which pairs sensibly with this.
The label mentions glucosamine. Is there shellfish in this?
No. Quatrefolic is a glucosamine salt of 5-MTHF, which is simply how the molecule is stabilised, and it contributes 377µg per capsule. The glucosamine used is not shellfish derived, which is why the product is suitable for vegans.
We flag it because seeing the word glucosamine on an ingredient list understandably makes people with a shellfish allergy stop and check.
Why is there maltodextrin in it?
Because 600µg is a very small amount of powder. A capsule needs something to fill it, and maltodextrin is the carrier doing that job.
Given the active weighs less than a milligram, a bulking agent is not optional here. The full list is that carrier, the HPMC capsule shell, and the Quatrefolic itself.
Is 600µg a lot?
It is 300% of the daily reference intake, so it is a deliberate dose rather than a token one. It sits comfortably below the 1000µg a day upper level set for folic acid supplementation in adults.
Do not exceed one capsule a day, and if you also take a multivitamin, check what folate is already in it before doubling up.
Is it suitable for vegans?
Yes. The capsule shell is plant-derived HPMC and there are no animal-derived ingredients, including the glucosamine.
How long does a bottle last?
90 capsules at one a day is a full three months, which works out at around 16p a day.
Store it in a cool, dry place out of reach of children. Not suitable for children.
What is your returns policy?
Every order is covered by our 30-day money-back guarantee. If it is not for you, contact us and we will refund you, no questions asked.
Try it risk-free for 30 days
Not completely happy? Send it back for a full refund, no questions asked. UK-made to GMP standards.
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